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Consequently, the extensive use of BHA in food products could pose risks of cytogenetic and molecular toxicity (Esazadeh et al

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Oxidative stress impairs NRF2 degradation by KEAP1 and stabilizes NRF2 protein, which then binds on the antioxidant response elements (AREs) in gene promoters and governs the transcription of genes involved in antioxidant defense and redox maintenance, including SLC7A11 (Fig